Aryl-4-ethynyl-isoxazole derivatives

Details Aryl-4-ethynyl-isoxazole derivatives Aryl-4-ethynyl-isoxazole derivatives

2007-05-24

2009-06-09

Shameem, Golam M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S224000, C544S336000, C546S268100, C546S268400, C546S272100, C548S240000, C514S252100, C514S378000

Reexamination Certificate

active

07544704

ABSTRACT:
The present invention is concerned with aryl-4-ethynyl-isoxazole derivatives of formula Iwherein R1to R5are as described in the specification and pharmaceutically acceptable salt thereof. This class of compounds has high affinity and selectivity for GABA A α5 receptor binding sites, being useful as a cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.

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