[(Aryl-1-pyrryl) methyl]-piperidinols and pyrrolidinols

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...


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26032625, 2603265C, C07D40106, C07D40306




Compounds of the formula ##STR1## wherein Y is halogen; R is hydrogen, alkyl, alkoxycarbonyl, phenoxycarbonyl, cyano, aralkyl, alkanoyl, aralkanoyl, hydroxyalkyl, benzoylalkyl, ##STR2## where p is an integer of 2 or 3; and R.sub.1 and R.sub.2 are the same or different and are hydrogen and lower alkyl; X is hydrogen and alkyl; Hal is a halogen; q is an integer of 0 or 1; m is an integer of 1 or 2 and n is an integer of 1, 2 or 3, where the sum of m and n is 3 or 4; and a pharmaceutically acceptable acid addition salt thereof, are provided. The compounds are useful intermediates in the preparation of Spiro[dihydrobenzofuran-piperidines and pyrrolidines], which are useful agents for relieving pain and for lowering blood pressure.

patent: 3647804 (1972-03-01), Rynbrandt et al.
Gschwend and Rodriguez "Organic Reactions", vol. 26, Chapter 1, pp. 1-7, 18, 21-22, 89, 93-95 and 114, (Wiley), (1979).


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