Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence
Reexamination Certificate
2006-05-24
2008-09-09
Helms, Larry R. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
8 to 10 amino acid residues in defined sequence
C530S332000
Reexamination Certificate
active
07423115
ABSTRACT:
This invention provides isolated peptides comprising a C-terminal fragment of an ARTS protein, isolated nucleotides encoding same, mimetics and small molecule analogues of same, and therapeutic applications comprising administering a peptide, nucleic acid, or mimetic compound of the present invention. This invention also provides isolated complexes comprising a C-terminal fragment of an ARTS protein and either an IAP protein, a Bir3 domain thereof, or a fragment thereof; compounds that bind or interact with same, and use of the compounds in therapeutic applications.
REFERENCES:
patent: 2005/0227302 (2005-10-01), Larisch et al.
Kieber-Emmons, T., Murali, R., and Greene, M.I. Therapeutic peptides and peptidomimetics. Current Opinion in Biotechnology, 1997. vol. 8, pp. 435-441.
Hruby, V.J. and Balse, P.M. Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads. Current Medicinal Chemistry, 2000. vol. 7, pp. 945-970.
Larisch, Lotan, Kerner, Eimeri, Parks, Gottfried, Reffey, De Caestecker, Danielpour, Book-Melamed, Timberg, Duckett, Lechleider, Steller, Orley, Kim and Roberts. A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. Nature Cell Biology, 2000. vol. 2, pp. 915-921.
Gottfried, Y., Rotem, A., Lotan, R., Steller, H., and Larisch, S. The mitochondrial ARTS protein promotes apoptosis through targeting XIAP. EMBO Journal, 2004. vol. 23, pp. 1627-1635.
Gussow Anne M
Helms Larry R.
Pearl Cohen Zedek Latzer LLP
SimeTRA Pharm Ltd
LandOfFree
ARTS C-terminus fragments and mimetics thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with ARTS C-terminus fragments and mimetics thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and ARTS C-terminus fragments and mimetics thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3986912