Artiodactyl epimorphine

Details Artiodactyl epimorphine Artiodactyl epimorphine

2005-01-04

2005-01-04

Romeo, David (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C536S023500

Reexamination Certificate

active

06838548

ABSTRACT:
An epimorphin protein having action to induce differentiation of milk protein-producing cells into a branched luminal structure in Artiodactyls including cows and sheep and comprising an amino acid sequence set forth in SEQ ID NO: 1 in the Sequence Listing; and a gene encoding said protein are provided. The epimorphin protein of the present invention can be used as a medicament for Artiodactyls or an agent for modifying animal properties. For example, the protein acts to enlarge the mammary gland of cows or sheep to prevent the gland from clogging, thereby a yield of a desired protein secreted in the milk of the animal is increased.

REFERENCES:
patent: 5726298 (1998-03-01), Hirai et al.
patent: 5837239 (1998-11-01), Hirai et al.
patent: 6127149 (2000-10-01), Hirai et al.
patent: 2152210 (1995-12-01), None
patent: 6-25295 (1994-02-01), None
patent: 6293800 (1994-10-01), None
patent: 8-325293 (1996-12-01), None
patent: 9-65885 (1997-03-01), None
patent: 9822505 (1998-05-01), None
An English Language abstract of JP 6-293800.
Oka et al., “Inductive influences of epimorphin on endothelial cells in vitro”, Exp. Cell Res., vol. 222, No. 1, Oct. 1, 1996, pp. 189-198.
Patent Abstracts of Japan for JP 9-65885.
Oka et al., “Inductive Influences of Epimorphin on Endothelial Cells in Vitro”,Experimental Cell Research,222, pp. 189-198 (1996).
Hirai et al., “Epimorphin: A Mesenchymal Protein Essential for Epithelial Morphogenesis”,Cell,vol. 69, pp. 471-481 (1992).
Gumbiner, “Epithelial Morphogenesis”,Cell,vol. 69, pp. 385-387 (1992).
Zha et al., “The Epimorphin Gene is Highly Conserved among Humans, Mice, and Rats and Maps to Human Chromosome 7, Mouse Chromosome 5, and Rat Chromosome 12”,Genomics,37, pp. 386-389 (1996).
Hirai, “Molecular Cloning of Human Epimorphin: Identification of Isoforms and Their Unique Properties”,Biochemical Biophysical Research Communications,vol. 191, No. 3, pp. 1332-1337 (1993).
Oka et al., SDB Meeting Abstract (B216) of 13th International Congress of Developmental Biology 56th SDB Annual Meeting,Developmental Biologyvol. 186 (1997).
Koshida et al., “Identification of Cellular Recognition Sequence of Epimorphin and Critical Role of Cell/Epimorphin Interaction in Lung Branching Morphogenesis”,Biochemical and Biophysical Research Communications,vol. 234, No. 2, pp. 522-525 (1997).
Hirai et al., “Epimorphin Functions as a Key Morphoregulator for Mammary Epithelial Cells”,The Journal of Cell Biology,vol. 140, pp. 159-169 (1998).
Panaretto, “Gene Expression of Potential Morphogens during Hair Follicle and Tooth Formation: a Review”,Reprod. Fertil. Dev.,pp. 345-360 (1993).
Matsuki et al., “Gene Expression of Epimorphin in Rat Incisor Ameloblasts”,Archs Oral Biol.,vol. 40, No. 2, pp. 161-164 (1995).

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