Artificial viral envelopes

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

264 41, 424 88, 424 89, 436829, A61K 9127, B01J 1302

Patent

active

052523489

ABSTRACT:
The production of artificial viral envelopes by a novel double-detergent dialysis technique is disclosed. Specifically exemplified is the production of HIV-1 and RSV viral envelopes. The resulting artificial viral envelopes are essentially identical to the natural virus with regard to characteristics which are relevant to immunogenicity.

REFERENCES:
patent: 4792331 (1988-12-01), Pillippot et al.
patent: 4927637 (1990-05-01), Morano et al.
Weiner, Advanced Drug Delivery Reviews 3, 307-341 (1989).
Deamer & Uster Liposome Prep. Methods & Mechanism Chapter 1, pp. 27-51, 1983.
Weder, Hans Georg, Othmar Zumbuehl (1985) "The Preparation Of Variably Sized Homogenious Liposomes For Laboratory, Clinical, and Industrial Use By Controlled Detergent Dialysis" Liposome Technology, Chapter 7, CRC Press, Boca Raton, Florida (US), pp. 79-107.
Laurence, J. (1990) "Review: Novel Vaccination and Antireceptor Strategies Against HIV," AIDS Res. and Human Retroviruses, vol. 6, No. 2, Mary Ann Liebert, Inc. Publishers, Cornell University Medical College, N.Y.
Ho, R. J. Y., R. L. Burke, R. C. Merigan (1989) "Antigen-Presenting Liposomes are Effective in Treatment of Recurrent Herpes Simplex Virus Genitalis in Guinea Pigs," J. Virology 63(7):2951-2958.
El Guink, N., R. M. Kris, G. Goodman-Snitkoff, P. A. Small, Jr., R. J. Mannino (1988) "Intranasal immunization with proteoliposomes protects against influenza," Vaccine 7:147-151.
Gould-Fogerite, S., J. E. Mazurkiewicz, D. Bhisitkul, R. J. Mannino (1988) "The Reconsititution of Biologically Active Glycoproteins into Large Liposomes: Use as a Delivery Vehicle to Animal Cells," Advances in Membrane Biochemistry and Bioenergetics, Plenum Press, N.Y., pp. 569-586.
Nussbaum, O., M. Lapidot, A. Loyter (1987) "Reconstitution of Functional Influenza Virus Envelopes and Fusion with Membranes and Liposomes Lacking Virus Receptors," J. Virol. 61(7):2245-2252.
Haddad, R. S., L. M. Hutt-Fletcher (1989) "Depletion of Glyocprotein gp85 from Virosomes Made with Epstein-Barr Virus Proteins Abolishes Their Ability to Fuse with Virus Receptor-Bearing Cells," J. Virol. 63:4998-5005.
Oth, D., G. Mercier, P. Perrin, M. L. Joffret, P. Sureau, L. Thibodeau (1987) "The Association of the Rabies Glycoprotein with Liposome (Immunosome) Induces an in Vitro Specific Release of Interleukin 2," Cellular Immunology 108:220-226.
Thibodeau, L., M. Chagnon, L. Flamand, D. Oth, L. Lachapelle, C. Tremblay, L. Montagnier (1989) "Role of liposomes on HIV envelope glycoprotein presentation and immune respone in mice," C. R. Adac. Sci. Paris 309(III): 741-747.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Artificial viral envelopes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Artificial viral envelopes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Artificial viral envelopes will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1902893

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.