Artificial RNAóS modified at the 2ó-hydroxyl group

Details Artificial RNAóS modified at the 2ó-hydroxyl group Artificial RNAóS modified at the 2ó-hydroxyl group

2005-03-02

2009-08-04

Lewis, Patrick T (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S022100, C536S023100

Reexamination Certificate

active

07569685

ABSTRACT:
The purpose of the present invention is to develop a system for efficiently constituting cyanoethyl ethers under mild conditions and probability of the ethers as functional groups for imparting specific functions and to make a contribution to the production of novel functional nucleic acids.The present invention relates to a nucleoside that is represented by the general formula (I) or a nucleotide derived therefrom:wherein X and Y may be the same as or different from each other, and are hydrogen, optionally substituted silyl group, 4-methoxytrityl group, 4,4′-dimethoxytrityl group or a group represented by the general formula (II):wherein R1 and R2 may be the same as or different from each other, representing an alkyl group having 1-7 carbon atoms such as diisopropyl, or they are united with each other to form a ring structure, R3 represents a protective group for a phosphoric acid such as 2-cyanoethyl; and B1 represents an optionally substituted pyrimidine or purine base.

REFERENCES:
patent: WO-02/20546 (2002-03-01), None
Pierre Martin; Ein neuer Zugang zu 2′-O--Alkylribonucleosiden und Eigenschaften deren Oligonucleotide, Helvetica Chimica Acta., vol. 78, pp. 486-504, 1995.
Morten Grotli et al., 2 -O-(Carbamoylmethyl) oligoribonucleotides., Terahedron, 55, 1999, pp. 4299-4314.
M.G.J. Beets et al., Macrocyclic oxalactones, Rev.trav.chim., 1953, vol. 72, pp. 411-418.

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