Artificial red cells

Details Artificial red cells Artificial red cells

1980-04-11

1983-06-28

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

4284022, 424177, A01N 2528, A61K 950, A61K 964, B01J 1302

Patent

active

043905218

ABSTRACT:
Artificial red cells have been prepared which comprise microdroplets of stroma-free, aqueous hemoglobin solution encapsulated in polymerized hemoglobin membranes which ae permeable to oxygen and impermeable to hemoglobin. These artificial red cells can be made having diameters generally less than four microns are able to maintain their individual integrity under conditions of flow with shear rates of up to about 2.times.10.sup.5 sec.sup.-1.

REFERENCES:
patent: 3879510 (1975-04-01), Kitajima et al.
patent: 4061736 (1977-12-01), Morris et al.
patent: 4133874 (1979-01-01), Miller et al.
Chang: "Artificial Cells", Chemtech, Feb. 1975, pp. 80-85.
Chang et al.: "Semipermeable Aqueous Microcapsules", Canadian Journal of Physiology and Pharmacology, vol. 44, (1966), pp. 115-128.

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