Liquid purification or separation – With preliminary chemical manufacture
Patent
1991-03-25
1992-05-26
Jones, W. Gary
Liquid purification or separation
With preliminary chemical manufacture
210209, 21032178, 21032187, 424424, 435284, 604 4, 604175, B01D 6306
Patent
active
051164949
ABSTRACT:
A device which serves as an artificial pancreas comprises a hollow fiber which is surrounded by islets of Langerhans enclosed in a housing. The islets are suspended in a temperature sensitive matrix which is sufficiently viscous to support islets at a temperature below about 45.degree. C. and sufficiently fluid to enable removal of islet suspension at a temperature above about 45.degree. C. A warm (e.g., 48.degree. to 50.degree. C.) solution may be flushed through the device to change the physical state of the temperature sensitive matrix from a semi-solid state to a liquified semi-gel state. The temperature sensitive supporting material also enables long term maintenance of islet cells in in vitro culture.
REFERENCES:
patent: 3734851 (1973-05-01), Matsumura
patent: 3827565 (1974-08-01), Matsumura
patent: 4242459 (1980-12-01), Chick et al.
patent: 4242460 (1980-12-01), Chick et al.
patent: 4323457 (1982-04-01), Sun et al.
patent: 4378016 (1983-03-01), Loeb
patent: 4578191 (1986-03-01), Jaffrin et al.
patent: 4778749 (1989-10-01), Vasington et al.
patent: 5002661 (1991-03-01), Chick et al.
William L. Chick et al. (1975) Science 187:847-849.
William L. Chick et al. (1975) Trans. Amer. Soc. Artif. Int. Organs XXI:8-14.
Anthony M. Sun et al. (1977) Diabetes 26(12):1136-1139.
William L. Chick et al. (1977) Science 197:780-782.
A. D. Whittemore et al. (1977) Trans. Amer. Soc. Artif. Int. Organs XXIII:336-340.
P. M. Galletti et al. (1978) Eur. Soc. Art. Organs 5:132-135.
S. P. Naber et al., Int. Congr. Series No. 500 Diabetes 1979, pp. 227-231.
W. J. Tze et al. (1979) Diabetologia, pp. 247-252.
N. J. Weinless and C. K. Colton (1983) Ann. N.Y. Acad. Sci. 413:421-423.
G. Reach et al. (1984) Diabetes 33:752-761.
C. K. Colton et al., "Development of Novel Semipermeable Tubular Membranes for a Hybrid Artificial Pancreas" pp. 541-555.
Y. Araki et al. (1985) Diabetes 34:850-854.
G. Reach et al. (1982) Journees Annuelles de Diabetologie de l'Hotel-Dieu, Flammarion, Paris, at pp. 147-159.
Chick William L.
Sullivan Susan J.
Jones W. Gary
W. R. Grace & Co.,-Conn.
LandOfFree
Artificial pancreatic perfusion device with temperature sensitiv does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Artificial pancreatic perfusion device with temperature sensitiv, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Artificial pancreatic perfusion device with temperature sensitiv will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-417354