Liquid purification or separation – With preliminary chemical manufacture
Patent
1991-03-25
1992-05-26
Dawson, Robert A.
Liquid purification or separation
With preliminary chemical manufacture
210209, 21032178, 21032187, 424424, 435284, 604 4, 604175, B01D 6306
Patent
active
051164930
ABSTRACT:
A device which serves as an artificial pancreas comprises a hollow fiber which is surrounded by islets of Langerhans enclosed in a housing. The islets are suspended in a semi-gel matrix or supporting material that is sufficiently viscous to physically support and maintain location of the islets about the hollow fiber, but sufficiently fluid to enable removal of the islet suspension from the device, followed by reseeding or replacement with fresh islet suspension. The matrix in which the islets are suspended preferably comprises calcium sodium alginate. The semi-gel supporting material also enables long term maintenance of islet cells in in vitro culture.
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Chick William L.
Rupp Randall G.
Dawson Robert A.
Kim Sun Uk
W. R. Grace & Co.,-Conn.
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