Artificial pancreas

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis

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623 12, 424424, 435178, A61F 202

Patent

active

060230096

ABSTRACT:
An artificial pancreas is described herein which comprises one or more viable and physiologically active pancreatic islet cells capable of producing insulin, encapsulated within a semipermeable spheroidal membrane comprising agar gel. Further disclosed are a method for producing agar microbeads, a tissue implantation method and a reseeding method for the artificial pancreas.

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Gin et al. Agarose encapsulation of islets of Langerhans: reduced toxicity in vitro. J. Microencapsulation. (1987) 4(3): 239-242.
Tun et al. A newly developed three-layer agarose microcapsule for a promising biohybrid artificial pancreas: rat to mouse xenotransplantation. Cell Transplantation. (1996) 5(5S): S59-S63.
Miyamoto et al. Improved large-scale isolation of breeder porcine islets: possibility of harvesting from nonheart-beating donor. Cell Transplantation. (1998) 7(4): 397-402.

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