Artificial oligosaccharide antigenic determinants

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424 85, 424180, 536 1, 536 4, 536 18, 536 53, 536115, 536116, 536119, 536120, A61K 3514, C07H 1306

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active

042384737

ABSTRACT:
Carbohydrate antigenic determinants containing a glycosidically linked bridging arm are synthesized and coupled to carrier molecules to form artificial antigens, and to solid supports to form immunoadsorbents. Various artificial antigens of the blood group type are prepared and applications shown. Specific examples are given to the synthesis of the Lewis-a, Lewis-b, A, B, and H(O) blood group antigens; to the preparation of antisera to these artificial antigens, to the preparation of immunoadsorbents specific for antibodies to these antigens, and to the detection of such antigens wherever they occur.

REFERENCES:
patent: 3356674 (1967-12-01), Ikeda et al.
patent: 3655645 (1972-04-01), Jacques
patent: 3729461 (1973-04-01), Pomeranz et al.
patent: 4137401 (1979-01-01), Lemieux et al.

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