Artificial nucleic acids of n-o bond crosslinkage type

Details Artificial nucleic acids of n-o bond crosslinkage type Artificial nucleic acids of n-o bond crosslinkage type

2004-08-25

2008-09-23

Lewis, Patrick T (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C514S043000

Reexamination Certificate

active

07427672

ABSTRACT:
An oligonucleotide analogue useful for the antisense method, etc., having excellent enzyme resistance, having potent selective binding affinity for single-stranded RNA, and further having an excellent triplex-forming capacity with double-stranded DNA, and a nucleoside analogue useful for its production are provided.Nucleoside analogues, which are compounds of the general formula (I) and salts thereof, and oligonucleotide analogues containing one or more of the nucleoside analogues:where Base is an aromatic heterocyclic group or the like optionally having a substituent; R1, R2and R3are each a hydrogen atom, a protective group for an amino group, a protective group for a hydroxyl group, a phosphate group, or —P(R4)R5[where R4and R5are each a hydroxyl group, a protected hydroxyl group, a mercapto group, a protected mercapto group, etc.]; m=0 to 2; and n=1 to 3].

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