Artificial nucleic acids and a method of making

Details Artificial nucleic acids and a method of making Artificial nucleic acids and a method of making

1998-03-10

2000-01-04

Crane, L Eric

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2534, C07H 2102, C07H 2104

Patent

active

060111437

ABSTRACT:
Provided is an artificial nucleic acid which has a double-stranded structure made of two oligonucleotides, where the oligonucleotide has in a sugar-phosphate backbone structure thereof a sugar moiety having a group having a metal-coordinating site, and the two oligonucleotides are bound together through a metal complex structure formed by coordination of the metal-coordinating site to a metal ion. Also provided is a nucleotide useful for synthesizing the artificial nucleic acid.

REFERENCES:
patent: 4818761 (1989-04-01), Sato et al.
patent: 5739022 (1998-04-01), Burstyn et al.
Gao et al., "Crystallographic Studies of Metal-Ion-DNA Interactions: Different Binding Modes of Cobalt(II), Copper (II) and Barium(II) to N.sup.7 of Guanines in Z-DNA and a Drug-DNA Complex," Nucleic Acids Research, 21(17), 4093-4101 (Aug. 25, 1993).
Kalvoda et al., "Acid-Catalyzed C-Ribofuranosylation of Benzene Derivatives; Some Novel Conversions of C-Ribofuranosyl Derivatives," Coll. Czech. Chem. Comm., 38(6), 1679-1692 (1973).
Scheller et al., "A Proton Nuclear Magnetic Resonance Study of Purine and Pyrimidine e Nucleoside 5'-Diphosphates. Extent of Macrochelate Formation in Monomeric Metal Ion Complexes and Promotion of Self-Stacking by Metal Ions," J. American Chemical Society, 10518), 5891-5900 (Sep. 7, 1983).
Shirotake, "Complexes Between Nucleic Acid Bases and Bivalent Metal Ions. III. Synthesis and Spectral Analyses of Cytosine-Calcium Chloride Complexes," Chemical & Pharmaceutical Bulletin, 28(3), 956-963 (Mar. 1980).
Kikuchi et al., "Synthesis and Self-Cleavage Reaction of a Chimeric Molecule Between RNase P-RNA and Its Model Substrate," Journal of Biochemistry, 117(1), 197-200 (Jan. 1995).
Battistuzzi et al., "Silver(I) Complexes of 4,6-Dimethylpyrimidine-2( H)-thion," Canadian Journal of Chemistry, 59(3), 591-596 (Feb. 1, 1981).
Summers, "Zinc Finger Motif for Single-Stranded Nucleic Acids? Investigation by Nuclear Magnetic Resonance," Journal of Cellular Biochemistry, 45(1), 41-48 (Jan. 1991).

Affiliated with

Also associated with

Rating

Artificial nucleic acids and a method of making does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Artificial nucleic acids and a method of making, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Artificial nucleic acids and a method of making will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1073537