Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1987-05-29
1990-11-27
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514 23, A61K 31685
Patent
active
049735829
ABSTRACT:
An artificial lung surfactant comprising (a) phosphatidyl choline and cardiolipin and/or phosphatidyl choline and cardiolipin and/or phosphatidyl glycerol in addition as phospholipids, wherein the content of the pospholipids is 80 to 95 wt % of the whole composition, (b) neutral lipids, wherein the content is 5 to 20 wt % of the whole composition, and (c) fatty acids, wherein the content is 0 to 10 wt % of the whole composition, and a remedy for respiratory distress syndrome containing the surfactant as an active principle.
REFERENCES:
Colowick et al., Methods in Enzymology, vol. XIV, 1969, pp. 276-277.
Freese et al., Biochim. Biophys. Acta, 1983, 750(1), pp. 47-89.
King, Federation Proceedings, vol. 33, No. 11, 1974, pp. 2238-2246.
Morley et al., The Lancet, pp. 64-68.
Freeze et al., Chemical Abstracts, vol. 98, 1983, No. 47272d.
Tanaka et al., Chemical Abstracts, vol. 98, 1983, No. 49063k.
Kobayashi Tsutomu
Kokubo Masayuki
Takada Yoshinori
Yoshida Tsunemasa
Brown Johnnie R.
Peselev Elli
Teijin Limited
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