Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-05-21
2009-08-18
Badio, Barbara P (Department: 1612)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S172000, C514S176000, C540S113000, C540S114000
Reexamination Certificate
active
07576055
ABSTRACT:
This invention relates to a highly efficient artificial low-density lipoprotein (LDL) carrier system for the targeted delivery therapeutic agents across the blood-brain barrier (BBB). In particular, this invention relates to artificial LDL particles comprised of three lipid elements: phosphatidyl choline, fatty-acyl-cholesterol esters, and at least one apolipoprotein. The present invention further relates to compositions, methods and kits comprising artificial LDL particles for targeting drugs to and across the BBB for the prevention and treatment of brain diseases.
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Alkon Daniel
Nelson Thomas
Quattrone Alessandro
Badio Barbara P
Blanchette Rockefeller Neurosciences Institute
Milbank Tweed Hadley & McCloy LLP
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