Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Solid support and method of culturing cells on said solid...
Patent
1996-07-01
1999-02-02
Marx, Irene
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Solid support and method of culturing cells on said solid...
435347, 435357, 435373, 435375, 435395, 435400, 435404, C12N 500
Patent
active
058664203
ABSTRACT:
Continuous cultures of pluripotent parenchymal hepatocytes were derived from the epiblasts of pig blastocysts. The cultures are feeder-dependent and grow slowly with doubling times of 3 to 4 days. They differentiate into large secretory duct-like structures or form small canaliculi. In combination with feeder cells and, optionally, adult pig hepatocytes and macrophages, the cells are useful in an artificial liver device which may be utilized as temporary liver support for the mitigation of the pathological effects of liver failure.
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Caperna Thomas J.
Kemp Christopher W.
Powell Anne M.
Pursel Vernon G.
Rexroad, Jr. Caird E.
Fado John
Graeter Janelle S.
Kerr Janet M.
Marx Irene
Silverstein M. Howard
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