Artificial liver apparatus and method

Details Artificial liver apparatus and method Artificial liver apparatus and method

2005-02-22

2005-02-22

Kim, John (Department: 1723)

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

C210S195200, C210S222000, C210S252000, C210S258000, C210S321600, C210S321720, C210S321780, C210S321870, C210S500230, C210S645000, C210S649000, C422S044000, C422S048000, C435S002000, C435S325000, C435S370000, C435S395000, C435S396000, C435S402000, C435S403000, C436S177000, C436S178000

Reexamination Certificate

active

06858146

ABSTRACT:
Artificial liver devices and methods for using the devices to purify a biological fluid are disclosed. The methods include the use of living hepatocytes (23) which are either unattached or attached to inert carriers and suspended in a cell culture medium which circulates in the devices with the hepatocytes (23). Blood or plasma passes on one side (7″) of semi-permeable membranes, on the other side (7) of which is the cell culture medium and across which is a concentration and/or pressure gradient. Solutes diffusing across the membrane into the cell culture medium are metabolized by the hepatocytes (23) and/or captured by additional removal means (4). Those undesirable substances which do not diffuse out of the blood or plasma into the hepatocyte containing culture medium are captured by additional removal means (50).

REFERENCES:
patent: 4335994 (1982-06-01), Gurth
patent: 4853324 (1989-08-01), Viles et al.
patent: 4963490 (1990-10-01), Churchouse et al.
patent: 5011607 (1991-04-01), Shinzato
patent: 5043260 (1991-08-01), Jauregui
Transactions of the American Society of Artificial Internal Organs, vol. XXI, issued 1975, C.F.W. Wolf et al, “Bilirubin Conjugation by An Artificial Liver Composed of Cultured Cells and Synthetic Capillaries”, pp. 16-27.*
Journal of Surgical Research, vol. 48, No. 4 issued Apr. 1990, W.S. Arnaout et al., “Development of Bioartificial Liver: Bilirubin Conjugation in Gunn Rats”, pp. 379-382.*
Olumide et al, Hepatic support with hepatocyte suspensions in a permeable membrane dialyzer, Surgery, Nov. 1977.

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