Artificial gene coding for authentic human serum albumin, use th

Details Artificial gene coding for authentic human serum albumin, use th Artificial gene coding for authentic human serum albumin, use th

1992-05-13

1999-03-09

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351723, 43525233, 4352542, 43525421, 4353201, 536 231, 536 235, C12N 1581, C07H 2104

Patent

active

058799079

ABSTRACT:
A structural gene coding for authentic human serum albumin, --optionally supplemented by an upstream triplet coding for methionine and optionally extended by a synthetic prepro.sup.x -leader-coding sequence--, wherein the codons of the nucleotide sequence have been selected with regard to a non-human host, e.g. yeast, chosen for expression of authentic human serum albumin, is disclosed.
Additionally there is disclosed a method of producing said gene.
There are also disclosed a recombinant DNA molecule comprising said strucural gene inserted into a vector, and a host transformed with said recombinant DNA molecule.
Furthermore there are disclosed a method of producing authentic human serum albumin, an authentic human serum albumin resulting from said method, and a pharmaceutical composition comprising said resulting human serum albumin.

REFERENCES:
patent: 4695623 (1987-09-01), Stabinsky
patent: 5013652 (1991-05-01), Strausberg et al.
Sharp, P.M. et al., "Codon usage in yeast: cluster analysis clearly differentiates and lowly expressed genes," Nucleic Acids Research, vol. 14, No. 13 (1986), pp. 5125-5143.
Bennetzen, J.L. and Hall, B.P., "Codon Selection in Yeast," Journal of Biological Chemistry, vol. 257, No. 6 (Mar. 25, 1982), pp. 3026-3031.

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