Artificial cpg single-stranded oligodeoxynucleotide and...

Details Artificial cpg single-stranded oligodeoxynucleotide and... Artificial cpg single-stranded oligodeoxynucleotide and...

2004-07-26

2009-02-17

Campell, Bruce (Department: 1648)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S002600, C424S180100, C424S185100, C424S192100, C424S193100, C435S091100, C435S091500, C536S023100, C536S023400, C536S023500, C536S023520, C536S025300

Reexamination Certificate

active

07491706

ABSTRACT:
The present invention provides a series of artificial CpG-containing single-stranded oligodeoxynucleotides (ODNs), each of which is consisted of single-stranded oligodeoxynucleotide DNA molecule containing one or more CpG(s), wherein said ODNs can stimulate human peripheral blood mononuclear cell (PBMC) to produce antiviral substances. These ODNs can protect the cells against the attack from virus, wherein said virus is preferably selected from the group consisted of influenza virus and single-stranded positive strand RNA virus such as SARS virus, hepatitis C virus, dengue virus and Japanese encephalitis virus. Moreover, the antiviral use of artificial CpG ODNs and its use for treating and preventing viral infection are also provided.

REFERENCES:
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patent: 031408214 (2004-05-01), None
patent: 03119840.6 (2004-09-01), None
patent: 03119841.4 (2004-09-01), None
Sheehan et al (2003) Nucleic Acids Research. 31(14): 4109-4118.
Peng, X et al. (2002) “Synthesis of single-stranded DNA probe using technique of primer length-asymmetric PCR”Chin. J. Lab Diagn.6:206-208.
Li, J. et al (2002) “The effect of transgenic expression of porcine interleukin-6 gene and cpg sequences on immune responses of mice inoculated with the gene vaccine of taenia solium of pig”High Tech Communications, pp. 26-30.
Yuan, Y-F. et al. (2002) “The roles of dna methelytion in human neoplasms”Chinese Journal of Cancer, 21:1267-1277.

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