Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Eye prosthesis – Corneal implant
Reexamination Certificate
2005-10-04
2010-12-28
Prebilic, Paul (Department: 3774)
Prosthesis (i.e., artificial body members), parts thereof, or ai
Eye prosthesis
Corneal implant
C623S006560, C424S427000, C435S180000, C351S16000R
Reexamination Certificate
active
07857849
ABSTRACT:
A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.
REFERENCES:
patent: 4391797 (1983-07-01), Folkman et al.
patent: 4452925 (1984-06-01), Kuzma et al.
patent: 4487865 (1984-12-01), Balazs et al.
patent: 4500676 (1985-02-01), Balazs et al.
patent: 4536554 (1985-08-01), Lim et al.
patent: 4693715 (1987-09-01), Abel, Jr.
patent: 4973493 (1990-11-01), Guire
patent: 4978352 (1990-12-01), Fedorov et al.
patent: 5030230 (1991-07-01), White
patent: 5067961 (1991-11-01), Kelman et al.
patent: 5087392 (1992-02-01), Burke et al.
patent: 5112350 (1992-05-01), Civerchia et al.
patent: 5171318 (1992-12-01), Gibson et al.
patent: 5258024 (1993-11-01), Chavel et al.
patent: 5282851 (1994-02-01), Jacob-LaBarre
patent: 5374515 (1994-12-01), Parenteau et al.
patent: 5458816 (1995-10-01), Ebner et al.
patent: 5458819 (1995-10-01), Chirila et al.
patent: 5580929 (1996-12-01), Tanaka et al.
patent: 5656210 (1997-08-01), Hill et al.
patent: 5660692 (1997-08-01), Nesburn et al.
patent: 5716633 (1998-02-01), Civerchia
patent: 5836313 (1998-11-01), Perez et al.
patent: 5962005 (1999-10-01), Saga et al.
patent: 5976648 (1999-11-01), Li et al.
patent: 6005160 (1999-12-01), Hsiue et al.
patent: 6224893 (2001-05-01), Langer et al.
patent: 6254637 (2001-07-01), Lee et al.
patent: 6372815 (2002-04-01), Sulc et al.
patent: 6391055 (2002-05-01), Ikada et al.
patent: 6645715 (2003-11-01), Griffith et al.
patent: 6673112 (2004-01-01), Nigam
patent: 6689165 (2004-02-01), Jacob et al.
patent: 6846875 (2005-01-01), Pennings et al.
patent: 6960617 (2005-11-01), Omidian et al.
patent: 7279507 (2007-10-01), Hu et al.
patent: 2001/0044482 (2001-11-01), Hu et al.
patent: 2002/0007217 (2002-01-01), Jacob et al.
patent: 2003/0022216 (2003-01-01), Mao et al.
patent: 2003/0100666 (2003-05-01), DeGroot et al.
patent: 2004/0049268 (2004-03-01), Noolandi et al.
patent: 2005/0147685 (2005-07-01), Osada et al.
patent: 2007/0005140 (2007-01-01), Kim et al.
patent: 2008/0119930 (2008-05-01), Osada et al.
patent: 2008/0317818 (2008-12-01), Griffith et al.
patent: WO 94/01468 (1994-01-01), None
patent: WO 03/093337 (2003-04-01), None
European search report for European Application No. 05807352.9 dated Mar. 30, 2010.
Gong et al. “Double-Network Hydrogels with Extremely High Mechanical Strength” (2003) Adv. Materials No. 14 pp. 1155-1158.
Cruise, G.M., D.S. Scharp and J.A. Hubbell, Characterization of permeability and network structure of interfacially photopolymerized poly(ethylene glycol) diacrylate hydrogels. Biomaterials, 1998. 19(14): p. 1287-94.
Padmavathi, N.C. and P.R. Chatterji, Structural characterization and swelling behavior of poly(ethylene glycol) diacrylate hydrogels. Macromolecules, 1996. 29: p. 1976-1979.
Merrett, K., C.M. Griffith, Y. Deslandes, G. Pleizier, and H. Sheardown, Adhesion of corneal epithelial cells to cell adhesion peptide modified pHEMA surfaces. J Biomater Sci Polym Ed, 2001. 12(6): p. 647-71.
Houseman, B.T. and M. Mrksich, The microenvironment of immobilized Arg-Gly-Asp peptides is an important determinant of cell adhesion. Biomaterials, 2001. 22(9): p. 943-55.
Hern, D.L. and J.A. Hubbell, Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing. J Biomed Mater Res, 1998. 39(2): p. 266-76.
Matsuda, T., K. Inoue and T. Sugawara, Development of micropatterning technology for cultured cells. ASAIO Transactions, 1990. 36(3): p. M559-62.
Tsuk, A.G., V. Trinkaus-Randall and H.M. Leibowitz, Advances in polyvinyl alcohol hydrogel keratoprostheses: protection against ultraviolet light and fabrication by a molding process. Journal of Biomedical Materials Research, 1997. 34(3): p. 299-304.
Gong et al. Double-Network Hydrogels with Extremely High Mechanical Strength. Adv. Materials 15 (14) 1155-1158, 2003.
Hern et al. Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing. J. Biomed. Materials Research 39(1) 266-276, 1998.
Evans et al. The use of corneal organ culture in biocompatibility studies. Biomaterials 23 1359-1367, 2002.
Carlsson, D.J., F. Li, S. Shimmura, and M. Griffith, Bioengineered corneas: how close are we? Curr Opin Ophthalmol, 2003. 14(4): p. 192-7.
Evans, M.D., G.A. McFarland, R.Z. Xie, S. Taylor, J.S. Wilkie, and H. Chaouk, The use of corneal organ culture in biocompatibility studies. Biomaterials, 2002. 23(5): p. 1359-67.
Mann, B.K., A.S. Gobin, A.T. Tsai, R.H. Schmedlen, and J.L. West, Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering. Biomaterials, 2001. 22: p. 3045-3051.
Carrasco Michael R.
Frank Curtis W.
Hu Yin
Koh Won-Gun
Myung David
Lumen Patent Firm
Prebilic Paul
Santa Clara University
The Board of Trustees of the Leland Stanford Junior Iniversity
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