Artificial chromosomes, uses thereof and methods for preparing a

Details Artificial chromosomes, uses thereof and methods for preparing a Artificial chromosomes, uses thereof and methods for preparing a

1996-07-15

2000-06-20

Railey, II, Johnny F.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 691, 4353201, 435325, 536 221, C12N 510, C12N 1510, C07H 2104

Patent

active

060776978

ABSTRACT:
Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heterochromatin are provided. Methods for use of the artificial chromosomes, including for gene therapy, production of gene products and production of transgenic plants and animals are also provided.

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