Artificial chimeras engineered to simulate multiple...

Details Artificial chimeras engineered to simulate multiple... Artificial chimeras engineered to simulate multiple...

2011-08-09

2011-08-09

Duffy, Patricia A (Department: 1645)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

Reexamination Certificate

active

07993844

ABSTRACT:
This invention provides safe, non-infectious chimeras that include the nucleic acid signature of most bacterial and viral biological threat agents. These chimeras mimic properties of threat agents and are useful as simulants to develop, evaluate, test, and train on nucleic acid-based biodetectors and diagnostic products of interest in biodefense, without the need for accessing or producing virulent agents.

REFERENCES:
Carrera et al (Conference proceeding, NTIS Accession No. ADA481840, Edgewood Chemical Biological Center, Aberdeen Proving Ground, MD, USDGRDR0820, Nov. 1, 2006, pp. 1-9).
Wei et al (Journal of Clinical Microbiology, 46(5):1734-1740, 2008).

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