Artificial carrier particles and method for preparation thereof

Details Artificial carrier particles and method for preparation thereof Artificial carrier particles and method for preparation thereof

1989-10-12

1991-10-22

Raymond, Richard L.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

436534, 525 541, 525 542, G01N 33543

Patent

active

050595423

ABSTRACT:
An artificial carrier particle comprising an anionic polymer and a synthetic polyamino acid having at least one carboxylic group and at least one amino group in its side chain, the complex being insolubilized by an aldehyde crosslinking agent. The artificial carrier particle is useful in immunoassay, in particular, particle immunoassay. The artificial carrier particles are obtained by preparing an aqueous solution containing an anionic polymer and a synthetic polyamino acid comprising at least one free carboxyl group and at least one free amino group in its side chain, adjusting the pH of the solution to 3.5 to 9.5 at room temperature or at progressively increasing temperature under stirring to form solution particles of a desired particle size, and insolubilizing the particles by an aldehyde crosslinking agent.

REFERENCES:
patent: 4276206 (1981-06-01), Katz
patent: 4342739 (1982-08-01), Kakimi et al.
patent: 4416813 (1983-11-01), Ikeda et al.
patent: 4935465 (1990-06-01), Garman
Hirayama et al., Chemical Abstracts 106:157696m, Abstract of JP-1,728, (1).

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