Artificial blood vessel

Details Artificial blood vessel Artificial blood vessel

1997-02-14

2000-04-25

Prebilic, Paul B.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Arterial prosthesis

Stent structure

623 11, 600 36, 600 37, A61F 206

Patent

active

060539399

ABSTRACT:
An artificial blood vessel formed into a tube from expanded polytetrafluoroethylene (PTFE), wherein the tube is composed of nodes connected by fibrils creating pores within the wall of the tube. The inner surface of the tube and surfaces of pores comprise a layer extending radially from the inner surface, toward the outer surface of the tube to a depth of 5% to 96%, are chemically treated to make the tube inner surface and pores hydrophilic. Tissue-inducing substances and anti-thrombotic substances are then covalently bonded to the hydrophilic inner surface of the tube and pores. An artificial blood vessel of the invention exhibits a good patency ratio for a long period of time.

REFERENCES:
patent: 4193138 (1980-03-01), Okita
patent: 4208745 (1980-06-01), Okita
patent: 4613517 (1986-09-01), Williams et al.
patent: 4822361 (1989-04-01), Okita et al.
patent: 5019393 (1991-05-01), Ito et al.
patent: 5028597 (1991-07-01), Kodama et al.
patent: 5034265 (1991-07-01), Hoffman et al.
patent: 5118524 (1992-06-01), Thompson et al.
patent: 5217492 (1993-06-01), Guire et al.
patent: 5591225 (1997-01-01), Okuda
patent: 5665114 (1997-09-01), Weadock et al.
Abstract of JP405269198A published Oct. 19, 1993.
Costello et al, "Surface-Selective Introduction of Specific Functionalities onto Poly(tetrafluoroethylene).sup.1 ", Macromolecules, vol. 20, No. 11, 1987, pp. 2819-2828.
Hegazy et al, "Radiation-Initiated Graft Copolymerization of Individual Monomer and Comonomer onto Polyethylene and Polytetrafluoroethylene Films", Journal of Applied Polymer Science, vol. 39, pp. 1029-1043.
Chapiro et al, "Synthesis of Permselective Membranes by Radiation Induced Grafting of Hydrophilic Monomers into Poly(Tetrafluoroethylene) Films", Polymer Engineering and Science, Feb. 1980, vol. 20, No. 3, pp. 202-205.
Morel et al, Structure and Morphology of Poly(Tetrafluoroethylene)-Poly(N-Vinylpyrrolidone) Copolymer Membranes, Journal of Applied Polymer Science, vol. 24, pp. 771-780.
Aiba et al, "Preparation of Poly(styrenesulfonic Acid)-Grafted Microporous Polytetrafluoroethylene Membranes and Their Activity as Hydrolysis Catalysts", Makromol. Chem., Rapid Commun. 7, pp. 91-96 (1986).
Tanfani et al, "Glycidyl Acrylate Plasma Glow Discharged Polymers", Biomaterials 1990, vol. 11, pp. 585-589.
Massia et al, "Human Endothelial Cell Interactions with Surface-Coupled Adhesion Peptides on a Nonadhesive Glass Substrate and Two Polymeric Biomaterials", Journal of Biomedical Materials Research, vol. 25, pp. 223-242.
Okada et al, "Evaluation of Collagen-Immobilized Percutaneous Implants", Polym. Mater. Sci. Eng., pp. 548-552 (1988).
Dekker et al, "Adhesion of Endothelial Cells and Adsorption of Serum Proteins on Gas Plasma-Treated Polytetrafluoroethylene", Biomaterials 1991, vol. 12, pp. 130-138.
Ramalanjaona et al, "The Effect of Fibronectin Coating on Endothelial Cell Kinetics in Polytetrafluoroethylene Grafts", J. Vascular Surgery, vol. 3, No. 2, (1986), pp. 264-272.
Seeger et al, "Improved in Vivo Endothelialization of Prosthetic Grafts by Surface Modification With Fibronectin", J. Vascular Surgery, vol. 3, No. 2, (1988), pp. 476-482.
Schneider et al, "Performed Confluent Endothelial Cell Monolayers Prevent Early Platelet Deposition on Vascular Prostheses in Baboons", Journal of Vascular.
Kesler et al, "Enhanced Strength of Endothelial Attachment on Polyester Elastomer and Polytetrafluoroethylene Graft Surfaces With Fibronectin Substrate", Journal of Vascular Surgery, vol. 3, No. 1, pp. 58-64 (1986).
Scott et al, "A Collagen Coated Vascular Prosthesis", Journal of Cardiovascular Surgery, vol. 28, 1987, pp. 498-504.

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