Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-06-26
2007-06-26
Priebe, Scott D. (Department: 1633)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C435S410000, C435S419000, C435S320100, C435S069100, C800S278000
Reexamination Certificate
active
10814858
ABSTRACT:
A bidirectional module for activation of gene expression and regulation of transcription in both directions is disclosed. The bidirectional module comprises multiple cis regulatory DNA sequence elements, strategically arranged to give a ‘Transcription Activating Module’ that achieves high level expression from a ‘Transcription Initiation Module’. The latter functions like a minimal promoter. The former activates transcription simultaneously in both the directions from the latter and also responds to several transcription inducing, external stimuli in both the directions. Since it is an artificially designed bidirectional transcription module, it has no equivalent DNA sequence in plant genome. This reduces the chances of the genes from being silenced by homology based mechanisms. A bidirectional promoter module as this, can therefore be used to develop efficient vectors for genetic engineering in plants.
REFERENCES:
patent: 6388170 (2002-05-01), Gan et al.
patent: 1 002 869 (2000-05-01), None
Sawant et al, Designing of an artificial expression cassette for the high-level expression of transgenes in plants, Theor Appl Genet (2001) vol. 102 pp. 635-644.
pUC19 map- downloaded Jul. 8, 2005.
Chaturvedi Chandra Prakash
Kiran Kanti
Mehrotra Rajesh
Tuli Rakesh
Vishwanath Sawant Samir
Council of Scientific and Industrial Research
Ladas and Parry LLP
Marvich Maria
Priebe Scott D.
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