Artificial beta cell

Details Artificial beta cell Artificial beta cell

1979-02-12

1981-01-20

Kamm, William E.

Surgery

Respiratory method or device

Ozone or ion generation

128260, A61J 700

Patent

active

042456347

ABSTRACT:
An artificial beta cell regulates blood glucose concentration in a subject by continuously analyzing blood from the patient and deriving a computer output signal to drive a pump which infuses insulin at a rate corresponding to the signal. A value of blood glucose concentration from the analyzed blood is used by a computer to determine a rate of change of this concentration which in turn is used to derive a projected blood glucose level. A sigmoidal relationship between the projected blood glucose concentration and the rate of infusion is used to determine the actual rate of infusion required and hence an output signal is fed to the pump to create this actual rate of insulin infusion.

REFERENCES:
patent: 3809871 (1974-05-01), Howard et al.
patent: 3837339 (1974-09-01), Aisenberg et al.
patent: 3946731 (1976-03-01), Lichtenstein
patent: 4003379 (1977-01-01), Ellinwood, Jr.
patent: 4055175 (1977-10-01), Clemens et al.
Pagurer et al., "Medical & Biological Engineering," vol. 10, No. 6, Nov. 1972, pp. 752-761.
Cahil, Jr. et al., "Diabetes," vol. 21, Supplement 2, 1972, pp. 703-712.

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