Artificial antibody

Details Artificial antibody Artificial antibody

1993-08-19

1995-12-12

Ziska, Suzanne E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 235, 5303873, C07H 2100, C07K 1600

Patent

active

054751004

ABSTRACT:
This invention provides an antibody having antigen binding activity and which has a heavy chain constant region into which has been introduced an RGDS amino acid sequence giving the antibody affinity for cells, including macrophages. The antibody exhibits artificial cell adhesive activity which is the newly expressed activity that results from insertion of the RGDS amino acid sequence. This antibody having artificial cell adhesive activity can accelerate the phagocytosis of macrophages, and can activate other effector cells. Therefore, this antibody contributes to the self-defense mechanism.

REFERENCES:
patent: 4614517 (1986-09-01), Ruoslahti
patent: 4816567 (1989-03-01), Cabilly et al.
Kameyana et al FEBS LETTS 244(2): 301-306 (Feb. 1989).
Maeda et al J.B.C. 264(26): 15165, 1989.
Symons et al Molecular Immunology 26(9):841, 1989.

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