Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis
Patent
1997-01-06
1998-07-21
Weiss, John G.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
623 13, 623 16, 623 20, 623901, 128898, A61F 202
Patent
active
057829152
ABSTRACT:
The invention provides an article of manufacture comprising a substantially non-immunogenic articular cartilage heterograft for implantation into humans. The invention further provides a method for preparing an articular cartilage heterograft by removing at least a portion of an articular cartilage from a non-human animal to provide a heterograft; washing the heterograft in saline and alcohol; subjecting the heterograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, freeze/thaw cycling, and optionally to chemical crosslinking. In accordance with the invention the heterograft has substantially the same mechanical properties as the native xenogeneic articular cartilage.
REFERENCES:
patent: 4034418 (1977-07-01), Jackson et al.
patent: 4344193 (1982-08-01), Kenny
patent: 4502161 (1985-03-01), Wall
patent: 4597266 (1986-07-01), Entrekin
patent: 4609627 (1986-09-01), Goldstein
patent: 4627853 (1986-12-01), Campbell et al.
patent: 4678470 (1987-07-01), Nashef et al.
patent: 4776853 (1988-10-01), Klement et al.
patent: 4801299 (1989-01-01), Brendel et al.
patent: 4880429 (1989-11-01), Stone
patent: 4932973 (1990-06-01), Gendler
patent: 5007934 (1991-04-01), Stone
patent: 5067962 (1991-11-01), Campbell et al.
patent: 5078744 (1992-01-01), Chvapil
patent: 5092894 (1992-03-01), Kenny
patent: 5116374 (1992-05-01), Stone
patent: 5158574 (1992-10-01), Stone
patent: 5171273 (1992-12-01), Silver et al.
patent: 5171322 (1992-12-01), Kenny
patent: 5192312 (1993-03-01), Orton
patent: 5306304 (1994-04-01), Gendler
patent: 5306311 (1994-04-01), Stone et al.
patent: 5358525 (1994-10-01), Fox et al.
patent: 5507810 (1996-04-01), Prewett et al.
patent: 5613982 (1997-03-01), Goldstein
Collins et al., (1994) Xenotransplantation, Characterization of Porcine Endothelial Cell Determinants Recognized by Human Natural Antibodies, 1:36-46.
Satake et al., (1994) Xenotransplantation, Limited Specificity of Xenoantibodies In Diabetic Patients Transplanted With Fetal Porcine Islet Cell Clusters. Main Antibody Reactivity Against .alpha.-linked Galactose-Containing Epitopes, 1:89-101.
LaVecchio et al., (1995) Transplantation, Enzymatic Removal of Alpha-Galactosyl Epitopes From Porcine Endothelial Cells Diminishes The Cytotoxic Effect of Natural Antibodies, vol. 60, 841-847.
Stone et al. (1993) Arthroscopy: the Journal of Arthroscopic and Related Surgery, 9:234-237.
Coterell et al. (1995) Transplantation, The Humoral Immune Response in Humans Following Cross-Perfusion of Porcine Organs, vol. 60, 861-868.
Galili, Immunology Today (1993), vol. 14, No. 10, 480-482.
Elves M.W. et al., An investigation Into The Immunogenicity Of Various Components Of Osteoarticular Grafts, The British Journal of Experimental Pathology, vol. 55, No. 4, pp. 344-351, Aug. 1974.
Cuddihy Francis K.
Weiss John G.
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