Articular cartilage gene therapy with recombinant vector...

Details Articular cartilage gene therapy with recombinant vector... Articular cartilage gene therapy with recombinant vector...

2007-10-05

2010-12-07

Nguyen, Quang (Department: 1633)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C435S456000, C536S023500

Reexamination Certificate

active

07846428

ABSTRACT:
The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of osteoarthritis in mammals, advantageously in humans, dogs, horses and cats, by intra-articular administration of the recombinant vectors and pharmaceutical compositions of the invention.

REFERENCES:
patent: 5266683 (1993-11-01), Oppermann et al.
patent: 2003/0220283 (2003-11-01), Glorioso et al.
patent: 2004/0167088 (2004-08-01), Wickham et al.
patent: 2004/0223953 (2004-11-01), Kung et al.
patent: 2005/0136042 (2005-06-01), Betz et al.
patent: 2005/0197304 (2005-09-01), DiCesare
patent: 2007/0190030 (2007-08-01), Pawliuk et al.
patent: 2009/0082301 (2009-03-01), Fischer
patent: WO 2007/056614 (2007-05-01), None
Franceschi, et al.Gene therapy for bone formation: in vitro and in vivo osteogenic activity of an adenovirus expressing BMP7. Journal of Cellular Biochemistry. vol. 78, No. 3. (2000) pp. 476-486.
Eto, et al.Development of PEGylated adenovirus vector with targeting ligand. International Journal of Pharmaceutics. vol. 354, No. 1-2 (2007) pp. 3-8.
Matthieu, et al.The conundrum between immunological memory to adenovirus and their use as vectors in clinical gene therapy. Molecular Biotechnology. vol. 34, No. 2 (2006) pp. 247-256.
Chubinskaya et al.OP-1/BMP-7 in cartilage repair. International Orthopaedics. vol. 31, No. 6 (2007) pp. 773-781.
Matthias et al.Cloning of the 5 ′-flanking region of the murine bone morphogenetic protein-7 gene. Molecular and Cellular Biochemistry. vol. 233, No. 1-2 (2002) pp. 31-37.

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