Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1988-07-05
1990-10-16
Rosen, Sam
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436518, 436519, 436520, G01N 33543, G01N 33554
Patent
active
049634780
ABSTRACT:
An article for performing solid-phase immunological assays and method for performing assays utilizing the article of the invention. A solid-phase support suitable for immunological assays is stained with an organic dye that has a net-positive charge and a hydrophobic aromatic ring structure. An immunologically reactive component having a net-negative charge is immobilized by the dye to the support through non-covalent interactions. The immunologically reactive component is tightly bound by the organic dye. This is advantageous when performing immunological assays utilizing automated washing instruments. A sample of a biological fluid is added to the article having the immunologically reactive component bound thereto to detect the presence of antigens or antibodies in the biological fluid specific for the bound immunological component. The presence of the antigen-antibody complex may be determined by any known method.
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Eatz Ralph A.
Plapp Fred V.
Sinor Lyle T.
Stone Darryl L.
Immucor, Inc.
Rosen Sam
Saunders David A.
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