Article comprising a dispensing container of polymeric material

Drug – bio-affecting and body treating compositions – Dentifrices

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424 52, 424 57, 424 58, 206277, 2065241, 2065243, 222107, 514718, 514721, 514900, 514901, 514902, A61K 716

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active

051357380

ABSTRACT:
An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container or bottle which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque acitivity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula. Also described is a method for inhibiting development of plaque on teeth.

REFERENCES:
patent: 3956480 (1976-05-01), Dichter et al.
patent: 4022880 (1977-05-01), Vinson et al.
patent: 4510127 (1985-04-01), Chang
patent: 4595613 (1986-06-01), Tavss et al.
patent: 4716034 (1987-12-01), Schelm
patent: 4830221 (1989-05-01), Mazzanobile

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