Arthritis treatment with hypoxanthine

Details Arthritis treatment with hypoxanthine Arthritis treatment with hypoxanthine

1988-06-02

1990-06-05

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 24, 536 26, A61K 3152, C07H 1916

Patent

active

049314319

ABSTRACT:
The complex mixture of substances in the product made from human placentae according to the procedure described in U.S. Pat. Nos. 3,526,697 and 4,335,040 includes hypoxanthine. Hypoxanthine is effective in treating arthritis, particularly if administered intradermally at low (e.g., not more than about 0.1 mg. of hypoxanthine per does) dose. Preferably, the dose level is not more than about 0.00002 mg. active material per dose, e.g., 0.1 cc of a dilution not stronger than about 1 mg. of active material per 5,000 ml of diluent.

REFERENCES:
patent: 3526697 (1970-09-01), Livingston
patent: 4081534 (1978-03-01), Elion et al.
patent: 4309419 (1982-01-01), Wolberg et al.
patent: 4322411 (1982-03-01), Vinegar et al.
Carson et al., Proc. Natl. Acad. Sci. (U.S.A.), 79(12), 3848-52, (1982).
Glazer, Robert I., Cancer Chemotherapy, Pharmacol., 4, 227-235 (1980).
Ratech, Howard et al., (1982), Cellular Immunology, 244-251.

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