Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2006-08-01
2006-08-01
Jiang, Shaojia Anna (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S060000, C514S557000, C514S772200, C514S772300, C514S773000, C514S777000, C514S779000, C514S054000, C514S781000, C514S895000, C514S023000, C536S103000, C536S120000, C536S122000, C536S123100, C424S440000, C424S493000, C424S500000
Reexamination Certificate
active
07084132
ABSTRACT:
A stable form of artemisinin wherein an artelinic acid or artesunic acid is complexed with cyclodextrin analogs, preferably, β-cyclodextrin. The complexed cyclodextrin artemisinin formulation shields the peroxide portion of the artemisinin backbone from hydrolytic decomposition rendering it stable in solution. Artelinic acid and cyclodextrin are placed into contact with one another to yield a 2:1 molecular species. Artesunic acid and cyclodextrin yield a 1:1 molecular species. The complexed cyclodextrin artemisinin formulation is effective for the treatment of malaria and is stable in solution for long periods of time.
REFERENCES:
patent: 6586464 (2003-07-01), Posner et al.
patent: 2002/0147177 (2002-10-01), Yuen et al.
patent: 685391 (1995-06-01), None
patent: WO/85 02767 (1983-12-01), None
patent: WO 01/62299 (2000-02-01), None
Bayomi, M. “Characterization of Arteether Interactions with Beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin”, Suadi Pharmaceutical Journal, Saudi Pharm. Soc., vol. 10, No. 1/2, Jan. 2002, pp. 36-43.
Usuda M., et al., “Interaction of antimalarial agent artemisinin with cyclodextrins”, Drug Dev. and Industrial Pharmacy, New York, NY, US, vol. 26, No. 6, Jun. 2000, pp. 513-619.
Wong, j. et al., “Improved oral bioavailability of artemisinin through inclusion complexation with beta-and-gamma-cyclodextrins”, Internat. Jour. of Pharmaceutics, Amsterdam, JL, vol. 227, No. 1-2, 2001 pp. 177-185.
Szejtli, Cyclodextrin Technology, textbook, (1988), Kiuwer Academic Publishers, p. 186-193, ISBN#90-227-2314-1.
IIIapakurthy, et al. Abstracr “Interactiona of artemisinin and its related compounds with hydroxypropyl-beta-cyclodextrin in solution state: Experimental and molecular -modeling studies” (2003).
Bhattacharjee Apurba K.
Hartell Mark G.
Hicks Rickey P.
Milhous Wilbur K.
VanHamont John E.
Arwine Elizabeth
Jiang Shaojia Anna
Khare Devesh
The United States of America as represented by the Secretary of
LandOfFree
Artemisinins with improved stability and bioavailability for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Artemisinins with improved stability and bioavailability for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Artemisinins with improved stability and bioavailability for... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3717306