Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2005-10-04
2005-10-04
Wilson, James O. (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S060000, C514S557000, C514S772200, C514S772300, C514S773000, C514S777000, C514S779000, C514S781000, C514S054000, C514S895000, C514S023000, C426S096000, C424S440000, C424S493000, C424S500000, C549S348000, C536S103000, C536S120000, C536S122000, C536S123100
Reexamination Certificate
active
06951846
ABSTRACT:
A stable form of artemisinin wherein an artelinic acid or artesunic acid is complexed with cyclodextrin analogs, preferably, β-cyclodextrin. The complexed cyclodextrin artemisinin formulation shields the peroxide portion of the artemisinin backbone from hydrolytic decomposition rendering it stable in solution. Artelinic acid and cyclodextrin are placed into contact with one another to yield a 2:1 molecular species. Artesunic acid and cyclodextrin yield a 1:1 molecular species. The complexed cyclodextrin artemisinin formulation is effective for the treatment of malaria and is stable in solution for long periods of time.
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Wong, J. et al., “Improved oral bioavailability of artemisinin through inclusion complexation with bets-and gamma-cyclodextrins”, Internat. Jour. of Pharmaceutics, Amsterdam, NL, vol. 227, No. 1-2, 2001, pp. 177-185.
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Iiiapakurthy, et al. Abstract Interactionof artemisinin and its related compounds with hydroxypropyl-beta-cyclodextrin in solution state: Experimental and molecular-modeling studies. (2003).
Bhattacharjee Apurba K.
Hartell Mark G.
Hicks Rickey P.
Milhous Wilbur K.
VanHamont John E.
Arwine Elizabeth
Khare Devesh
The United States of America as represented by the Secretary of
Wilson James O.
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