Artemisinin dimer compounds having anticancer activity

Details Artemisinin dimer compounds having anticancer activity Artemisinin dimer compounds having anticancer activity

1995-06-29

1997-10-14

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514450, C07D32102

Patent

active

056774680

ABSTRACT:
Disclosed herein are novel artemisinin dimers of structure ##STR1## which possess anticancer activity.

REFERENCES:
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Chen et al., (CA 105:97718n), @1986.
"Synthesis of a Novel Ring Contracted Artemisinin Derivative," Bioorganic & Medicinal Chemistry Letters 4(5):751-752 (1994).
"Qinghaosu (Artemisinin): An Antimalarial Drug from China,", D.L. Klayman, Science 228:1049-1055 (May 1985).
"Cytotoxicity of Artemisinin-Related Endoperoxides to Ehrlich Ascites Tumor Cells," Journal of Natural Products, 56(6):849-856 (Jun. 1993).
"Artemisinin (Qinghaosu): A New Type of Antimalarial Drug," Department of Chemistry, University of St. Andrews, Scotland, Anthony R. Butler; Chemical Society Reviews (1992), pp. 85-90.
"Extraordinarily Potent Antimalarial Compounds: New, Structurally Simple, Easily Synthesized, Tricyclic 1,2,4-Trioxanes," Journal of Medicinal Chemistry vol. 35, No. 13, (1992).
"Artemisinin," The Royal Society of Tropical Medicine and Hygiene, vol. 88 Supplement 1 (Jun. 1994).

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