Arteminolide derivatives and process for the manufacture thereof

Details Arteminolide derivatives and process for the manufacture thereof Arteminolide derivatives and process for the manufacture thereof

1997-08-05

1998-09-01

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30794

Patent

active

058012540

ABSTRACT:
Arteminolides obtained from Artemisia sylvatica MAXIMOWICZ and having a core structure of formula (I) or an isomeric structure thereof are effective farnesyl-protein transferase inhibitors as well as angiogenesis suppressors, and, accordingly, they are useful for the treatment of various cancers and angiogenesis-related diseases. ##STR1##

REFERENCES:
Jakupovic et. al., Phytochemistry, vol. 26 (10), pp. 2777-2779, 1987.

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