Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1982-07-13
1989-11-14
Rollins, John W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C07H 1916, A61K 3170
Patent
active
048809187
ABSTRACT:
A process by which the growth of malignant cells, e.g., human malignant cells, in a host is arrested and killed by treatment of the cells with low doses of adenosine 5'-diphosphate (ADP) or adenosine 5'-triphosphate (ATP), while normal cells thereof are substantially unaffected, is disclosed. ADP and ATP are capable of permeating through the plasma membrane of a variety of tumor cells, e.g., human tumor cells, and are incorporated into the cellular acid-soluble nucleotide pools of these cells, without prior breakdown to adenosine 5'-monophosphate (AMP) or adenosine, resulting in inhibition of DNA synthesis and cellular growth followed by cell death, while normal animal cells do not allow penetration of ADP or ATP through their plasma membrane without prior degradation.
REFERENCES:
patent: 4396609 (1983-08-01), Daum et al.
Chemical Abstracts, 98:119267f, (1983).
Chemical Abstracts, 91:15297e, (1979).
Chemical Abstracts, 99(19):156206b, (1983).
Chemical Abstracts, 97(25):214032p.
Rapaport et al., Cancer Research, 43,4402-4406, Sep., 1983.
Elmaleh et al., Proc. Natl. Acad. Sci. U.S.A., vol. 81, pp. 918-921, Feb., 1984.
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