Array of nucleic acid probes on biological chips for diagnosis o

Details Array of nucleic acid probes on biological chips for diagnosis o Array of nucleic acid probes on biological chips for diagnosis o

1997-01-09

1999-01-19

Marschel, Ardin H.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

422 50, 422 681, 435 6, 4352831, 435810, 436501, 536 231, 536 241, 536 243, 536 2431, 536 2432, 536 2433, 935 77, 935 78, C12Q 168

Patent

active

058612424

ABSTRACT:
The invention provides an array of oligonucleotide probes immobilized on a solid support for analysis of a target sequence from a human immunodeficiency virus. The array comprises at least four sets of oligonucleotide probes 9 to 21 nucleotides in length. A first probe set has a probe corresponding to each nucleotide in a reference sequence from a human immunodeficiency virus. A probe is related to its corresponding nucleotide by being exactly complementary to a subsequence of the reference sequence that includes the corresponding nucleotide. Thus, each probe has a position, designated an interrogation position, that is occupied by a complementary nucleotide to the corresponding nucleotide. The three additional probe sets each have a corresponding probe for each probe in the first probe set. Thus, for each nucleotide in the reference sequence, there are four corresponding probes, one from each of the probe sets. The three corresponding probes in the three additional probe sets are identical to the corresponding probe from the first probe or a subsequence thereof that includes the interrogation position, except that the interrogation position is occupied by a different nucleotide in each of the four corresponding probes.

REFERENCES:
patent: 4656127 (1987-04-01), Mundy
patent: 4683195 (1987-07-01), Mullis et al.
patent: 5002867 (1991-03-01), Macevicz
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5202231 (1993-04-01), Drmanac et al.
patent: 5273632 (1993-12-01), Stockham et al.
patent: 5527681 (1996-06-01), Holmes
Elder, J.K., "Analysis of DNA oligonucleotide hybridization data by maximum entropy," Maximum Entropy and Bayesian Methods, pp. 1-10, Paris (1992).
Hagstrom et al., "Maximum likelihood genetic sequence reconstruction from oligo content," Sep. 1992, Argonne Nat'l Laboratory Preprint MCS-P309-0592.
Lipshutz, Robert J., "Likelihood DNA sequencing by hybridization," J. of Biomolecular Structure & Dynamics 11:637-653 (1993).
Luo et al., "Cellular protein modulates effects of human immunodeficiency virus type 1 rev," J. of Virology 68:3850-3856 (1994).
Maxam et al., "A new method for sequencing DNA," Proc. Natl. Acad.Sci. USA (1977) 74:560-564.
Maxam et al., "Sequencing end-labeled DNA with base-specific chemical cleavages," Methods in Enzymology 65:499-560 (1980).
Querat et al., "Nucleotide sequence analysis of SA-OMVV, a Visna-related ovine lentivirus: phylogenetic history of lentiviruses," Virology 175:434-447 (1990).
Ratner et al., "Complete nucleotide sequence of the AIDS virus, HTLV-III," Nature 313:277-284 (1985).
Sambrook et al., Molecular Cloning, Cold Spring Harbor Laboratory Press, 1989, pp. 1145-1147.
Sanger et al., "DNA sequencing with chain-terminating inhibitors," Proc. Natl. Acad. Sci. USA (1977) 74:5463-5467.
Southern et al., "Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: evaluation using experimental models," Genomics (1992) 13:1008-1017.
Stratagene 1988 Catalog, "Gene Characterization Kits," p. 39.
Wain-Hobson et al., "Nucleotide sequence of the AIDS virus, LAV," Cell 40:9-17 (1985).

Affiliated with

Also associated with

Rating

Array of nucleic acid probes on biological chips for diagnosis o does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Array of nucleic acid probes on biological chips for diagnosis o, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Array of nucleic acid probes on biological chips for diagnosis o will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1245657