Chemistry: analytical and immunological testing – Optical result
Reexamination Certificate
2006-06-06
2006-06-06
Housel, James (Department: 1641)
Chemistry: analytical and immunological testing
Optical result
C436S538000, C436S519000, C436S806000, C436S807000, C422S051000, C422S067000, C422S063000, C422S067000, C435S004000, C435S006120, C435S007100, C435S007200, C435S007210, C435S007230, C435S007920, C435S007930, C435S007940, C435S007950, C427S002120, C427S002130, C427S483000, C427S059000, C427S077000
Reexamination Certificate
active
07056746
ABSTRACT:
A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. This invention is also for a method and apparatus to direct the lateral motion and induce the assembly into planar arrays of cells on semiconductor surfaces in response to temporally and spatially varying electric fields and to projected patterns of illumination.
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Haab et al., “Sing
Li Alice Xiang
Seul Michael
BioArray Solutions Ltd.
Bowker Julie
Do Pensee T.
Housel James
Mirabel Eric P.
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