Aroyl-piperidine derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514307, 514314, 514319, 544283, 546146, 546169, 546205, A61K 31445, A61K 3147, A61K 31505, C07D40112

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active

059655623

ABSTRACT:
The invention relates to novel N-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-4-(azanaphthoyl-amino)-piperi dines of the formula ##STR1## wherein X and Y are each independently of the other N and/or CH and the ring A is unsubstituted or mono- or poly-substituted by substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl; and the salts thereof, to the use thereof, to processes for the preparation thereof and to pharmaceutical compositions comprising a compound according to the invention or a pharmaceutically acceptable salt thereof.

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Becker et al Chem Abstract 56: 7263i (1961).
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Becker et al Chem Abstract 68:38700v (1968).
Watling Tips vol. 13, pp. 266-269, Jul. 1992 "Nonpeptide Antagonists Herald New Era in Tachykinin Research."
McLean et al, Science 251, 437-439, Jan. 25, 1991 "Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P(NK) Receptor Antagonist."
Snider et al Science 251, 435-437, Jan. 25, 1991 A potent nonpeptide substance `P (NK) Receptor`.

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