Aromatically substituted azacycloalkyl-alkanediphosphonic acids

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

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514 80, 514 82, 514 85, 514 88, 514 89, 514 91, 544243, 544337, 540450, 540480, 540481, 540542, 546 22, 546 23, 546 24, 548413, A61K 31675, C07F 965

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048717207

ABSTRACT:
Aromatically substituted azacycloalkylalkanediphosphonic acids of the formula ##STR1## in which R represents an aromatically substituted azacycloaliphatyl radical that is bonded to the group alk by way of a nitrogen atom and that optionally contains an additional nitrogen atom, and alk represents a divalent aliphatic radical, and their salts, can be used for the treatment of illnesses that can be attributed to calcium metabolism disorders. They are manufactured, for example, by reacting a compound of the formula

REFERENCES:
patent: 4666895 (1987-05-01), Bosies et al.
patent: 4687767 (1987-08-01), Bosies et al.
patent: 4719203 (1988-01-01), Bosies et al.
patent: 4761406 (1988-08-01), Flora et al.
Chem. Abstr. 93: 181017Z (1980), p. 190, Nissan Chem. Ind.
Derwent Abstract 84-010294/02 of Soviet 1002300A (1983).

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