Aromatic sulfonamide derivatives, their use as enzyme inhibitors

Details Aromatic sulfonamide derivatives, their use as enzyme inhibitors Aromatic sulfonamide derivatives, their use as enzyme inhibitors

1997-01-17

1997-09-02

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514253, 514255, 514307, 514419, 514423, 514602, 514604, 544363, 544372, 544373, 544391, 546146, 548495, 548537, 564 84, 564 92, 564 94, A61K 31495, A61K 3118, C07D40306, C07C31114

Patent

active

056631740

ABSTRACT:
Aromatic sulfonamide derivatives, particularly benzenesulfonamide, 4-fluorobenzenesulfonamide, 5-chloro-1-naphthalenesulfonamide and 5-isoquinolinesulfonamide derivatives are provided that inhibit Ca.sup.2+ -dependent enzymes and proteins such as Phospholipase A.sub.2, protein kinases such as Protein Kinase C, and inhibit membrane fusion, thereby being a valuable drug for the treatment of inflammation, arthritis, infarction, nephritis and many other types of tissue injury.

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