Aromatic retinoic acid analogues

Details Aromatic retinoic acid analogues Aromatic retinoic acid analogues

1982-11-19

1985-07-30

Killos, Paul J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

560 8, 560 65, 562474, 562405, 564170, 564171, 564174, 560 64, 514544, 514134, 514617, C07C 6976

Patent

active

045323437

ABSTRACT:
Aromatic retinoic acid analogues of the formula ##STR1## where X is hydrogen or fluorine, Y is hydrogen, halogen of atomic number 9 or 17, hydroxy, alkyl of 1 to 2 carbon atoms or alkoxy of 1 to 2 carbon atoms and R is hydroxy, alkoxy, aroxy, or NR.sup.1 R.sup.2 where R.sup.1 is hydrogen, alkyl, or aryl and R.sup.2 is alkyl or aryl, with the proviso that when Y is hydrogen, X is fluorine. These retinoids are useful as chemopreventive agents for inhibiting tumor promotion in epithelial cells and for treating nonmalignant skin disorders.

REFERENCES:
Dawson, M. I. et al., J. Med. Chem. 1981, 24, 583-592.

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