Aromatic pyrrolidine amide prolyl endopeptidase inhibitors

Details Aromatic pyrrolidine amide prolyl endopeptidase inhibitors Aromatic pyrrolidine amide prolyl endopeptidase inhibitors

1996-01-26

1998-12-08

Wu, Shean C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514408, 514418, 514422, 514423, 548400, 548467, 548468, 548469, 548492, 548518, 548525, C07D20914, C07D40502, A01N 4336, A01N 4338

Patent

active

058471553

ABSTRACT:
A series of aromatic pyrrolidine derivatives and suitable pharmaceutically acceptable salts thereof are disclosed. These compounds are useful as PEP inhibitors in the treatment of Alzheimer's disease, amnesia, dementia, anxiety ischemia, or stroke.

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patent: 4857537 (1989-08-01), Toda et al.
patent: 4956380 (1990-09-01), Toda et al.
patent: 4977180 (1990-12-01), Toda et al.
Chemical Abstracts, 46983s (Dupont), 94, 544.
Chemical Abstracts, 74803k (Kyowa), 84, 433.
Chemical Abstracts, 99709a (Indian J. Chem), 74, 481.

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