Aromatic prostaglandin analogues

Details Aromatic prostaglandin analogues Aromatic prostaglandin analogues

1978-05-05

1979-12-04

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

26032633, 26037643, 26037645, 424267, 546205, 546220, 546221, C07D20726, A61K 3140

Patent

active

041772830

ABSTRACT:
Compounds of formula (I): ##STR1## wherein: m is 1 or 2; n is 4 to 8; X is CO, protected CO, or CROH wherein R is hydrogen or C.sub.1-4 alkyl and wherein the OH moiety may be protected; R.sub.1 is hydrogen or CO.sub.2 R.sub.1 represents an ester group in which the R.sub.1 moiety contains from 1 to 12 carbon atoms; R.sub.3 is hydroxy, or protected hydroxy; R.sub.2 and R.sub.4 are separately hydrogen, C.sub.1-9 alkyl, C.sub.5-8 cycloalkyl, C.sub.5-8 cycloalkyl-C.sub.1-6 alkyl, phenyl, phenyl C.sub.1-6 alkyl, naphthyl, naphthyl C.sub.1-6 alkyl, any of which phenyl or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or nitro groups; or R.sub.2 and R.sub.4 taken with the carbon atom to which they are joined represent a C.sub.5-8 cycloalkyl group; and salts thereof; except that when one of R.sub.2 and R.sub.4 is hydrogen or C.sub.1-4 alkyl then the other of R.sub.2 and R.sub.4 cannot be hydrogen or C.sub.1-9 alkyl; have useful pharmacological properties including anti-gastric secretion, bronchodilator and platelet aggregation inhibition activities.

REFERENCES:
patent: 3975399 (1976-08-01), De Franco et al.
patent: 4003911 (1977-01-01), Scribner

Affiliated with

Also associated with

Rating

Aromatic prostaglandin analogues does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aromatic prostaglandin analogues, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aromatic prostaglandin analogues will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-91909