Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1978-06-15
1980-08-05
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544295, 544312, 544393, 544396, A61K 31505, C07D40306
Patent
active
042162165
ABSTRACT:
Compounds of general formula ##STR1## are disclosed wherein appropriate substituents for R.sup.1, R.sup.2 to R.sup.5, R.sup.6, A, Q, X, and Z are defined for these novel hexahydropyrimidines. Procedures for the preparation of these compounds are also given. Because of the highly effective serotonin antagonistic activity in combination with a strong inhibiting effect on thrombocyte aggregation and good compatibility these compounds are effective in treating migraine. Additionally, the compounds also exhibit an anti-histamine activity, cause an increase in erythrocyte fluidity, a psychotropic activity, a weak bradykinin antagonism and hypotensive effects.
REFERENCES:
patent: 2672460 (1954-03-01), Conroy
patent: 3466280 (1969-09-01), Loux
patent: 4100282 (1978-07-01), Renth et al.
Anagnostopulos Hiristo
Gebert Ulrich
Weber Rolf-Ortwin
Coughlan, Jr. Paul M.
Hoechst Aktiengesellschaft
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