Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-12-12
1993-10-05
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514415, 548455, 548469, A61K 3140, A61K 31405, C07D20904
Patent
active
052505642
ABSTRACT:
Compounds are provided which are crossreactive with peptides such as those bound by G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have the general structure: ##STR1## wherein at least one of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 or R.sub.6 comprises a chemical functional group which causes the compounds to be crossreactive with the peptide of interest.
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Veber and Hirschmann, et al., Proc. Natl. Acad. Sci. USA, 1978 75 2636.
Thorsett, et al., Biochem. Biophys. Res. Comm., 1983 111 166.
Veber and Hirschmann, et al., Life Sciences, 1984, 34, 1371.
Veber and Hirschmann, et al., Nature, 1981, 292.
Raynor and Reisine, Journal of Pharmacology and Experimental Therapeutics, 1989, 251;2, 510.
Reisine, et al., Brain Research, 1979, 177, 241.
Hirschmann Ralph
Leahy Ellen
Sprengeler Paul
Lee Mary C.
McKane Joseph K.
Trustees of the University of Pennsylvania
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