Aromatic or inter-oxa 2-decarboxy-2-hydroxymethyl-PGF.alpha. com

Details Aromatic or inter-oxa 2-decarboxy-2-hydroxymethyl-PGF.alpha. com Aromatic or inter-oxa 2-decarboxy-2-hydroxymethyl-PGF.alpha. com

1985-09-30

1987-01-20

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C 43205

Patent

active

046381007

ABSTRACT:
The present invention comprises certain aromatic and inter-oxa analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. These prostaglandin F.alpha. analogs exhibit prostaglandin F.alpha. activity and are accordingly useful for the same pharmacological purposes as the corresponding prostaglandins.

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patent: 4028397 (1977-06-01), Schaub et al.
patent: 4055602 (1977-10-01), Nelson
patent: 4060534 (1977-11-01), Bundy
Karim (I), The Prostaglandins: Progress in Research (1972) 1-46.
Rosenthale et al., Advances in Prostaglandin and Thromboxane Research, vol. 1 (1976), 477-493.
Pike et al., Nobel Symposium 2: 161 (1967), 161-171.

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