Aromatic mustards and aziridines and pharmaceutical uses thereof

Details Aromatic mustards and aziridines and pharmaceutical uses thereof Aromatic mustards and aziridines and pharmaceutical uses thereof

1992-07-16

1994-07-19

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514616, 5483641, 5483725, 5483741, 564 86, 564153, 564155, 564156, A61K 31165, C07C23556

Patent

active

053310047

ABSTRACT:
The invention relates to novel polybenzamide mustards having anticancer and hypoxia-selective properties, to methods of preparing the novel compounds, and to the use of these compounds as anticancer agents.
The compounds have general formula (I) ##STR1## wherein M and M.sub.1 separately represent H, aziridinyl, N(Et)CH.sub.2 CH.sub.2 Y or N(CH.sub.2 CH.sub.2 Y).sub.2, where Y is Cl, Br, I or OSO.sub.2 Me; R and R.sub.1 separately represent up to three of H, NO.sub.2, aza (ring CH.dbd.replaced by N.dbd.), CH.sub.2 Q, SO.sub.2 NHQ or CONHQ, where Q is H, Me, (CH.sub.2).sub.n NMe.sub.2 (CH.sub.2).sub.n NHC(.dbd.NH)NH.sub.2 and n.dbd.2-4);

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