Aromatic ketones having cardiovascular activity

Details Aromatic ketones having cardiovascular activity Aromatic ketones having cardiovascular activity

1980-03-12

1981-11-24

Hines, Robert V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

26050117, 26034849, 26034863, 424316, 424330, 548215, 548218, 564304, C07C 9306

Patent

active

043026010

ABSTRACT:
The present invention relates to phenoxypropane having the formula ##STR1## in which R.sup.1 and R.sup.2 are like or unlike and each is an alkyl group having 1-4 carbon atoms, R.sup.3 is hydrogen or an alkyl group having 1-4 carbon atoms, R.sup.4 is a halogen atom, preferably fluorine, chlorine or bromine, including their optical isomers and also their addition salts with acids.
These compounds are of therapeutic value in the treatment of cardiovascular conditions.
The invention also relates to methods of synthesis of these products including a synthesis which involves the production, as a intermediate of an 8-aza-4,9-dioxa-2,3-benzo-bicyclo-[4,2,1]-octane having the formula ##STR2## in which R.sup.1 and R.sup.4 are as above defined.

REFERENCES:
patent: 3501769 (1970-03-01), Crowther et al.
patent: 3637852 (1972-01-01), Koppe et al.
patent: 3875149 (1975-04-01), Wooldridge
patent: 4252825 (1981-02-01), Demarne

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